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2020

Innovations in Retina:

SPECTRALIS

Wavefront Aberrometry

Beginning of long-term “Ocular Hypertension Treatment Study” (OHTS) Zangwill, Weinreb, et al.

First Doppler Flowmetry (HRF) Michelson, Chauhan

First HRT3 replaces HRTII with AI (GPS), TCA

Patent granted for use of phase plates for aberration reduced imaging

Two-Photon Imaging:

2017

1996

1994

cSLO:

2015

First in vivo two-photon FA on animals

First MPOD Study, using HRA Brinkmann, Wolf, et al.

2005

Swept-source OCT prototype for anterior segment imaging

SPECTRALIS

2014

First commercial compact cSLO with objective measurement of ONH with automatic image alignment for correction of eye motion (HRT)

1991

First two-photon fluorescence imaging on in vivo rabbit eye Jester, La Schiazza

First commercial multi-modal cSLO with real-time image averaging, noise reduction and image composites, AF and simultaneous FA / ICGA video (HRA2)

First in vivo two-photon imagingof retina (FA and ICGA) in rodentsJayabalan, et al.

Datamining:

Backwards

HEYEX 2 – Next generation image management platform

2010

Modified SPECTRALIS HYDRA in Switzerland / Moorfields Hasler, Meier, et al.

2004

First HRT3 replaces HRT II with AI (GPS), and TCA

Forwards

First SPECTRALIS HRA+OCT with simultaneous cSLO and OCT with real-time TruTrack eye-tracking with dynamic visualization (colocalization of retina and OCT image)

2018

2016

Healthcare IT

First commercial version of objective measurement of the BMO-MRW with APS: GMPE

First cSLO in vivo corneal microscopy (HRTII RCM prototype) Guthoff, Stave, Stachs, et al.

In vivo measurement of time resolved auto fluorescence of the human eye Schweitzer, et al.

1998

2019

First mobile OCT with real-time eye tracking (FLEX) – Aqueous angiography study Huang, et al.

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2002

Anterior Segment

Moorfields Regression Analysis (MRA) Wollstein, Garway-Heath, et al.

SD-OCT:

2006

NASA Ocular Health Study with SPECTRALIS OCT on ISS

2013

NASA Space Associated Neuro Ocular Syndrome study (SANS) - OCT2 Module in space Lee, Mader, et al.

First commercial prototype for high resolution OCT

Innovations in Glaucoma

First MultiLine study in rodents Leung, Weinreb et al.

First commercial prototype cSLO (Heidelberg Instruments) Zinser, Bille

1984

2008

Heidelberg DNA :

Lab prototype of compact cSLO system for two-photon imaging

Patent granted for use of phase plates for aberration reduced imaging

First OCT Angiography with full axial resolution, real-time eye-tracking, AutoRescan and dynamic visualization with Hybrid Angiography

HEIDELBERG EYE EXPLORER

Blue Fundus Auto Fluorescence using HRA2 prototype Roider, et al.

2001

Innovations in Anterior Segment:

First commercial compact clinical system for objective measurement of the ONH – became gold standard for progression analysis (HRT II)

First prototype device for Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Wolf, Dysli, et al.

First cSLO in vivo corneal microscopy (HRTII RCM prototype) Guthoff, Stave, Stachs, et al.

Blue/Green/IR laser cSLO imaging (MultiColor)

Heidelberg DNA:

2012

First AutoRescan using eye-tracking on SPECTRALIS OCT

First Simultaneous Widefield OCT and Widefield cSLO imaging

First Oral FA with HRA Garcia, et al.

2007

1999

First Simultaneous Widefield OCT and Widefield cSLO imaging

Macular Pigment Optical Volume (MPOV), standardized measurement of macular pigment Nolan, et al.

SS-OCT:

Moorfields Regression Analysis (MRA) Wollstein, Garway-Heath, et al.

First Simultaneous FA / ICGA video technology Holz

1997

First prototype device for Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO) Wolf, Dysli, et al.

Topographic Change Analysis (TCA) Chauhan

Analytics

First anterior segment imaging with SPECTRALIS OCT

2000

First ICGA study with HRA Bartsch, Schmidt

First commercial version of objective measurement of the BMO-MRW with APS: GMPE

NASA Ocular Health Study with SPECTRALIS OCT on ISS

First anterior segment imaging with SPECTRALIS OCT

Datamining

Slit-Lamp OCT

First commercial multi-modal cSLO with real-time image averaging, noise reduction and image composites, AF and simultaneous FA / ICGA video (HRA2)

Prototype software for BMO-MRW with APS study Chauhan, Buorgoyne, et al.

Swept-source OCT prototype for anterior segment imaging

Quantitative autofluorescence and Macular Pigment Optical Density (MPOD) cSLO Delori, Nolan, et al.

NASA Space Associated Neuro Ocular Syndrome study (SANS) - OCT2 Module in space Lee, Mader, et al.

Image montage using image averaging technology on HRA

First anterior segment imaging with SPECTRALIS OCT

Ultra-widefield cSLO

Real-time swept-source OCT imaging in cataract and refractive surgery (VICTUS, B+L)

Quantitative autofluorescence and Macular Pigment Optical Density (MPOD) cSLO Delori, Nolan, et al.

Beginning of long-term “Ocular Hypertension Treatment Study” (OHTS) Zangwill, Weinreb, et al.

First commercial compact cSLO with objective measurement of ONH with automatic image alignment for correction of eye motion (HRT)

Noise reduction technology by real-time image averaging on HRA

HRT

First HRT3 replaces HRTII with AI (GPS), TCA

Scrolling through the enface OCTA images

SD-OCT

Scrolling through the enface OCTA images

Blue/Green/IR laser cSLO imaging (MultiColor)

First mobile OCT with real-time eye tracking (FLEX) – Aqueous angiography study Huang, et al.

First AAO with Heidelberg Engineering

Noise reduction technology by real-time image averaging on HRA

Forward

In vivo measurement of time resolved auto fluorescence of the human eye Schweitzer, et al.

Backward

First simultaneous widefield OCT and widefield cSLO imaging

First commercial prototype for high resolution OCT

Lab system combining two-photon imaging with FLIO

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Real-world data mining through structured EMR Denniston, et al.

First commercial prototype for high resolution OCT

First Auto-Rescan using eye tracking on SPECTRALIS OCT

First commercial prototype cSLO (Heidelberg Instruments) Zinser, Bille

First Commercial cSLO: Laser Tomographic Scanner (LTS, Heidelberg Instruments) Zinser

First commercial compact clinical system for objective measurement of the ONH – became gold standard for progression analysis (HRT II)

1989

High Magnification Module

Lab system combining two-photon imaging with FLIO

First SPECTRALIS HRA+OCT with simultaneous cSLO and OCT with real-time TruTrack eye-tracking with dynamic visualization (colocalization of retina and OCT image)

Lab system combining two-photon imaging with FLIO

Scrolling through the enface OCTA images

First in vivo two-photon imaging of retina (FA and ICGA) in rodents Jayabalan, et al.

Swept-source OCT multimodal biometric system for anterior segment (ANTERION)

First MPOD Study, using HRA Brinkmann, Wolf, et al.

Adaptive Optics

Innovation in Healthcare IT:

First commercial prototype cSLO (Heidelberg Instruments) Zinser, Bille

ANTERION

Aberration corrected retinal imaging Dreher, Weinreb

First research prototype of adaptive optics (Heidelberg Instruments)

First OCT Angiography with full axial resolution, real-time eye-tracking, AutoRescan and dynamic visualization with Hybrid Angiography

First prototype for ex vivo two-photon fluorescence imaging of the human eye

First Hartmann-Shack Wavefront Aberrometry sensor including Zernike Polynomials Zinser, Bille

1988

First Combination of High Magnification Imaging with customized phase plates Holz

First Commercial cSLO: Laser Tomographic Scanner (LTS, Heidelberg Instruments) Zinser

First lab two-photon excited fluorescence imaging in vitro human eyes Bille, Holz, Schneider, et al.

Retina

Lab prototype of compact cSLO system for two-photon imaging

Glaucoma

Swept-source OCT multimodal biometric system for anterior segment (ANTERION)

First Combination of High Magnification Imaging with customized phase plates Holz

Glaucoma Probability Score with HRT II First machine learning classification algorithm (AI) Swindale, Stjepanovic, et al.

Blue Fundus Auto Fluorescence using HRA2 prototype Roider, et al.

Macular Pigment Optical Volume (MPOV), standardized measurement of macular pigment Nolan, et al.

Real-time swept-source OCT imaging in cataract and refractive surgery (VICTUS, B+L)

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First Combination of High Magnification Imaging with customized phase plates Holz

Glaucoma Probability Score with HRT II. First machine learning classification algorithm (AI) Swindale, Stjepanovic, et al.

First SPECTRALIS HRA+OCT with simultaneous cSLO and OCT with real-time TruTrack eye-tracking with dynamic visualization (colocalization of retina and OCT image)

Quantitative autofluorescence and Macular Pigment Optical Density (MPOD) cSLO

Real-world data mining through structured EMR Denniston, et al.

Beginning of long-term “Ocular Hypertension Treatment Study” (OHTS) Zangwill, Weinreb, et al.

Topographic Change Analysis (TCA) Chauhan

Slit-Lamp OCT

First OCT Angiography with full axial resolution, real-time eye-tracking, AutoRescan and dynamic visualiza-tion with Hybrid Angiography

Prototype software for BMO-MRW with APS study Chauhan, Buorgoyne, et al.

Moorfields Regression Analysis (MRA) Wollstein, Garway-Heath, et al.

First SPECTRALIS HRA+OCT with simultaneous cSLO and OCT with real-time TruTrack eye-tracking with dynamic visualization (colocalization of retina and OCT image)

Blue/Green/IR laser cSLO imaging (MultiColor)

Scientific Timeline

First mobile OCT with real-timeeye tracking (FLEX) –Aqueous angiography studyHuang, et al.

Two-Photon Imaging

First cSLO in vivo corneal microscopy (HRTII RCM prototype) Guthoff, Stave, Stachs, et al.

First commercial compact clinical system for objective measurement of the ONH – became gold standard for progression analysis (HRT II)

Swept-source OCT multimodal biometric system for anterior segment (ANTERION)

Lab prototype of compact cSLO system for two-photon imaging

Heidelberg DNA

First prototype for ex vivo two-photon fluorescence imaging of the human eye

First Commercial cSLO: Laser Tomographic Scanner (LTS, Heidelberg Instruments) Zinser

First research prototype of adaptive optics (Heidelberg Instruments)

Glaucoma Probability Score with HRT II First machine learning classification algorithm (AI) Swindale, Stjepanovic, et al.

Prototype software for BMO-MRW with APS study Chauhan, Buorgoyne, et al.

First mobile OCT with real-timeeye tracking (FLEX) –Aqueous angiography studyHuang, et al.

First Simultaneous FA / ICGA video technology Holz et al.

First lab two-photon excited fluorescence imaging in vitro human eyes Bille, Holz, Schneider, et al.

Innovation in Healthcare IT:

Aberration corrected retinal imaging Dreher, Weinreb

NASA Space Associated Neuro Ocular Syndrome study (SANS) – OCT2 Module in space Lee, Mader, et al.

SS-OCT

First Hartmann-Shack Wavefront Aberrometry sensor including Zernike Polynomials Zinser, Bille

First commercial prototype for high resolution OCT

cSLO

Healthcare IT

Anterior Segment:

Glaucoma

Retina

Spectralis

ANTERION

HRT

HEIDELBERG EYE EXPLORER

1984 – 2021

cSLO

SD-OCT

Datamining

Two-Photon Imaging

Heidelberg DNA

Analytics

Wavefront Aberrometry

SS-OCT

Adaptive Optics