1984

First research prototype of adaptive optics (Heidelberg Instruments)
First commercial prototype cSLO (Heidelberg Instruments)
Zinser, Bille

1990

Heidelberg Engineering was formed
Zinser, Schoess

1991

First AAO with Heidelberg Engineering

First commercial compact cSLO with objective measurement of ONH with automatic image alignment for correction of eye motion (HRT)

1997

First simultaneous FA / ICGA video technology
Holz, et al.

1998

Image montage using image averaging technology on HRA

Noise reduction technology by image averaging on HRA

Moorfields Regression Analysis (MRA)
Wollstein, Garway-Heath, et al.

First compact clinical system for objective measurement of the ONH – became gold standard for progression analysis (HRT II)

1999

First Oral FA with HRA
Garcia, et al.

2000

Glaucoma Probability Score with HRT II
First machine learning classification algorithm (AI)
Swindale, Stjepanovic, et al.

Topographic Change Analysis (TCA)
Chauhan, et al.

2002

Lab prototype of compact cSLO system for two-photon imaging

First cSLO in vivo corneal microscopy (HRTII RCM prototype)
Guthoff, Stave, Stachs, et al.

2006

First SPECTRALIS HRA+OCT with simultaneous cSLO and OCT with real-time TruTrack eye tracking with dynamic visualization (colocalization of retina and OCT image)

First lab two-photon excited fluorescence imaging in vitro human eyes
Bille, Holz, Schneider, et al.

2007

First AutoRescan using eye tracking on SPECTRALIS OCT

2008

First MultiLine study in rodents
Leung, Weinreb, et al.

First prototype for ex vivo two-photon fluorescence imaging of the human eye Slit-Lamp OCT

2010

First two-photon fluorescence imaging on in-vivo rabbit eye
Jester, La Schiazza, et al.

First anterior segment imaging with SPECTRALIS OCT

2012

Blue/Green/IR laser cSLO imaging (MultiColor)

2014

First prototype device for Fluorescence Lifetime Imaging Ophthalmoscopy (FLIO)
Wolf, Dysli, et al.

First commercial version of objective measurement of the BMO-MRW with APS: GMPE

Swept-source OCT prototype for anterior segment imaging

HEYEX 2 – Next generation image management platform

2015

First in vivo two-photon FA on animals

Patent granted for use of phase plates for abberation reduced imaging

First simultaneous widefield OCT and widefield cSLO imaging

2016

First OCT Angiography with full axial resolution, real-time eye-tracking, AutoRescan and dynamic visualization with Hybrid Angiography

Real-time swept-source OCT imaging in cataract and refractive surgery (VICTUS, B+L)

2017

Real-world data mining through structured EMR
Denniston, et al.

First in vivo two-photon imaging of retina (FA and ICGA) in rodents
Jayabalan, et al.

NASA Space Associated Neuro Ocular Syndrome study (SANS) – OCT2 in space
Lee, Mader, et al.

Scrolling through the enface OCTA images

First mobile OCT with real-time eye tracking (FLEX) – Aqueous angiography study
Huang, et al.

2019

First combination of High Magnification Imaging with customized phase plates
Holz, et al.

Swept-source OCT multimodal biometric system for anterior segment (ANTERION)

2020

First commercial prototype for high resolution OCT

Macular Pigment Optical Volume (MPOV), standardized measurement of macular pigment
Nolan, et al.